Research

My lab is interested in complex interactions, network dynamics, as well as conscious and hedonic experiences.

We combine computational approaches in neuroimaging, ultrasonic brain stimulation, and psychopharmacological neuromodulation to understand the role of complex brain network dynamics in the emergence of conscious and hedonic experiences in the healthy and diseased brain.

We support open science.
We support the development of fMRIprep.

News

2023

Tiny Blue Dot Foundation

PI: Crone Co-Investigators: Lanzenberger, Spies

The role of transformative experiences and brain network dynamics in hedonic response to psychedelics: paving the way for broader utilization https://www.tinybluedotfoundation.org/projects-overview#uv

900.000 Dollar | 3 years

2022

ERC Starting Grant Interview Invitation

Got the interview (yay!). But did not get the funding (no worries – I’ll try again)

2022

Rudolphina News

How ketamine can work against depression

https://rudolphina.univie.ac.at/en/university-of-vienna-how-ketamine-can-work-against-depression

2021

FWF #Connecting Minds

PI: Pelowski, Crone, Spee

Transdisciplinary project „Unlocking the Muse: Transdisciplinary approaches to understanding and applying the intersection of artistic creativity and Parkinson’s disease“

1 Million Euro | 5 years


2020

Interuniversity Cluster Projects

PI: Crone
Co-PI: Lanzenberger

Interdisciplinary project „Unraveling the aesthetic mind in anhedonia: Insights from pharmacological imaging of the human brain“

300 K Euro | 3 years


2018

Trainee Professional Development Award

The Trainee Professional Development Award (TPDA) recognizes undergraduate and graduate students and postdoctoral fellows who demonstrate scientific merit and excellence in research.


2017

K99/R00 Pathway to Independence Award

PI: Crone

Interdisciplinary project „Cell-specific mechanism and functional connectivity in TBI using optogenetic fMRI“

186 K / 1 Million Dollar | 5 years

People

Julia Sophia Crone

Principle Investigator

Maximilian Kathofer

PhD Student

Franz Roman Schmid

PhD Student

Publications

Under Review

Crone, J.S. & Leder, H. (under review). A neuroscientific view on context and complexity of aesthetic experiences.

Schnetzer, L., Crone, J.S., et al., & Kronbichler, M. (under review). Diagnosis and prognosis in disorders of consciousness: An active paradigm fMRI study.

Peer-reviewed Journals

Kathofer, M., et al., & Crone, J.S. (2023). Bridging neurodegenerative diseases and artistic expressivity: The significance of testable models and causal inference. Physics of Life Review

Frohlich, J., Bayne, T., Crone, J.S., DallaVecchia, A., Kirkeby-Hinrup, A., Mediano, P.A.M., Moser, J., Talar, K., Gharabaghi, A., Preissl, H. (2023). Not with a “zap” but with a “beep”: measuring the origins of perinatal experience. Neuroimage. DOI: 10.1016/j.neuroimage.2023.120057

Leder, H. & Crone, J.S. (2023). Changes in style as a diagnostic medical tool or a way to study creativity in art? Comment on “Can we really ‘read’ art to see the changing brain? A review and empirical assessment of clinical case reports and published artworks for systematic evidence of quality and style changes linked to damage or neurodegenerative disease” by Pelowski et al. (2022). Physics of Life Review.

Weiler, M., Cassebb, R.F., de Campos, B.M, Crone, J.S., Lutkenhoff, E.S., Vespa, P.M., Monti, M.M. (2022). Evaluation of denoising strategies in resting-state fMRI datasets of traumatic brain injury patients (EpiBioS4Rx). Human Brain Mapping. 43(15):4640-4649. DOI: 10.1002/hbm.25979

Cain, J.A., Spivak, N.M., Coetzee, J.P., Crone, J.S., Johnson, M.A, Lutkenhoff, E.S., Real, C., Buitrago-Blanco, M., Vespa, P.M., Schnakers, C., Monti, M.M. (2022). Ultrasonic Deep Brain Neuromodulation in Acute Disorders of Consciousness: A Proof-of-Concept. Brain Sciences, 12(4):428. DOI: 10.3390/brainsci12040428

Frohlich, J. Crone, J.S., Johnson, M.A., Lutkenhoff, E.S., Spivak, N.M., Dell’Italia, J., Hipp, J.F., Shrestha, V., Ruiz Tejeda, J.E., Real, C., Vespa, P.M., Monti, M.M. (2022). Neural oscillations track recovery of consciousness in acute traumatic brain injury patients. Human Brain Mapping. DOI: 10.1002/hbm.25725

Cain, J.A., Visagan, S., Johnson, M.A., Crone, J.S., Blades, R., Spivak, N.M., Shattuck, D., and Monti, M.M. (2021). Online and offline effects of subcortical focused ultrasound neuromodulation in healthy humans. Scientific Reports, 11:6100. DOI: 10.1038/s41598-021-85504-y

Cain, J.A., Spivak, N.M., Coetzee, J.P. Crone, J.S., Johnson, M.A., Lutkenhoff, E.S., Real, C., Buitrago-Blanco, M., Vespa, P.M., Schnakers, C. and Monti, M.M. (2021). Behavioral improvement in Chronic Disorders of Consciousness after Thalamic Low Intensity Focused Ultrasound Sonication. Brain Stimulation. DOI: 10.1016/j.brs.2021.01.008

Crone, J.S., Vespa, P.M., Lutkenhoff, E.S., & Monti, M.M. (2020). A systematic investigation of the association between network dynamics in the human brain and the state of consciousness. Neurosci Conscious, 2020(1). DOI:10.1093/nc/niaa008

Kronbichler, L., Stelzig-Schöler, R., Pearce, B. G., Tschernegg, M., Said-Yürekli, S., Crone, J.S., Uscatescu L.-C., Reich, L. A., Weber, S., Aichhorn, W., Perner, J. & Kronbichler, M. (2019). Reduced Spontaneous Perspective Taking in Schizophrenia. Psychiatry Research: Neuroimaging, 292:5-12. DOI: 10.1016/j.pscychresns.2019.08.007

Annen, J., Frasso, G., Heine, L., Di Perri, C., Martial, C., Cassol, H., Demertzi, A., Crone, J.S., Naccache, L., Laureys, L., and Coma Science Group Collaborators (2018). Regional brain volumetry and brain function in severely brain injured patients. Annals of Neurology, 83(4):842-853. DOI: 10.1002/ana.25214

Crone*, J.S., Bio*, B.J., Vespa, P.M., Lutkenhoff, E.S., & Monti, M.M. (2018). Restoration of thalamo-cortical connectivity after brain injury: recovery of consciousness, complex behavior, or passage of time? Journal of Neuroscience Research, 96(4):671-687. DOI: 10.1002/jnr.24115

Crone, J.S., Lutkenhoff, E.S., Bio, B.J., Laureys, S., & Monti, M.M. (2017). Testing proposed neuronal models of effective connectivity within the cortico-basal ganglia-thalamo-cortical loop during loss of consciousness. Cerebral Cortex, 27(4):2727-2738. DOI: 10.1093/cercor/bhw112

Pletzer, B., Crone, J.S., Kronbichler, M. & Kerschbaum, H. (2016). Menstrual cycle and hormonal contraceptive dependent changes in intrinsic connectivity of resting state brain networks correspond to behavioral changes due to hormonal status. Brain Connectivity, 6 (7):572-85. DOI: 10.1089/brain.2015.0407

Demertzi, A., Antonopoulos, G., Heine, L., Voss, H. U., Crone, J.S., de Los Angeles, C., Bahri, M.A., Di Perri, C., Vanhaudenhuyse, A., Charland-Verville, V., Kronbichler, M., Trinka, E., Phillips, C., Gomez, F., Tshibanda, L., Soddu, A., Schiff, N.D., Whitfield-Gabrieli, S., & Laureys, S. (2015). Intrinsic functional connectivity differentiates minimally conscious from unresponsive patients. Brain, 138 (9), 2619-2631. DOI: 10.1093/brain/awv169

Crone, J.S., Schurz, M., Höller, Y., Bergmann, J., Monti, M., Schmid, E., & Kronbichler, M. (2015). Impaired consciousness is linked to changes in effective connectivity of the posterior cingulate cortex within the default mode network. Neuroimage, 110, 101-109. DOI: 10.1016/j.neuroimage.2015.01.037

Höller, Y., Thomschewski, A., Bergmann, J., Kronbichler, M., Crone, J.S., Schmid, E.V., Butz, K., Höller, P., Nardone, R., & Trinka, E.  (2014). Connectivity biomarkers can differentiate patients with different levels of consciousness. Clin Neurophysiol, 125(8), 1545-1555. DOI: 10.1016/j.clinph.2013.12.095

Mayrhauser, L., Bergmann, J., Crone, J., & Kronbichler, M. (2014). Neural repetition suppression: evidence for perceptual expectation in object-selective regions. Front Hum Neurosci, 8, 225. DOI: 10.3389/fnhum.2014.00225

Schurz, M., Kronbichler, M., Crone, J., Richlan, F., Klackl, J., & Wimmer, H. (2014). Top-down and bottom-up influences on the left ventral occipito-temporal cortex during visual word recognition: An analysis of effective connectivity. Hum Brain Mapp, 35(4), 1668-1680. DOI: 10.1002/hbm.22281

Demertzi, A., Gomez, F., Crone, J.S., Vanhaudenhuyse, A., Tshibanda, L., Noirhomme, Q., Thonnard, M., Charland-Verville, V., Kirsch, M., Laureys, S., & Soddu, A. (2014). Multiple fMRI system-level baseline connectivity is disrupted in patients with consciousness alterations. Cortex, 52, 35-46. DOI: http://dx.doi.org/10.1016/j.cortex.2013.11.005

Das, T., Abeyasinghe, P., Crone, J.S., Sosnowski, A., Laureys, S., Owen, A., & Soddu, A. (2014). Highlighting the structure-function relationship of the brain with the Ising Model and Graph Theory. BioMed Research International, 2014. DOI: 10.1155/2014/237898

Crone, J.S., Soddu, A., Höller, Y., Vanhaudenhuyse, A., Schurz, M., Bergmann, J., Schmid, E., Trinka, E., Laureys, S., & Kronbichler, M. (2014). Altered network properties of the fronto-parietal network and the thalamus in impaired consciousness. Neuroimage: Clinical, 4, 240-248. DOI: 10.1016/j.nicl.2013.12.005

Höller, Y., Bergmann, J., Thomschewski, A., Kronbichler, M., Höller, P., Crone, J.S., Schmid, E.V., Butz, K., Nardone, R., & Trinka, E. (2013). Comparison of EEG-features and classification methods for motor imagery in patients with disorders of consciousness. PLoS One, 8, e80479. DOI: 10.1371/journal.pone.0080479

Golaszewski, S., Seidl, M., Frick, K., Kunz, A., Leis, S., Kronbichler, M., Crone, J., Nardone, R., Trinka, E., & Gerstenbrand, F. (2013). Functional diagnosis of brain function in patients with severe chronic disorders of consciousness. Journal of the Neurological Sciences, 333, e546-e546. DOI: 10.1016/j.jns.2013.07.1919

Höller, Y., Thomschewski, A., Bergmann, J., Kronbichler, M., Crone, J.S., Schmid, E.V., Butz, K., Höller, P., & Trinka, E. (2013). EEG-response consistency across subjects in an active oddball task. PLoS One, 8, e74572. DOI: 10.1371/journal.pone.0074572

Crone, J.S., Höller, Y., Bergmann, J., Golaszewski, S., Trinka, E., & Kronbichler, M. (2013). Self-related processing and deactivation of cortical midline regions in disorders of consciousness.Front Hum Neurosci, 7, 504. DOI: 10.3389/fnhum.2013.00504

Crone*, J.S., Tschernegg*, M., Eigenberger, T., Schwartenbeck, P., Fauth-Buhler, M., Lemenager, T., Mann, K., Thon, N., Wurst, F.M., & Kronbichler, M. (2013). Abnormalities of functional brain networks in pathological gambling: a graph-theoretical approach. Front Hum Neurosci, 7, 625. DOI: 10.3389/fnhum.2013.00625

Höller, Y., Bergmann, J., Kronbichler, M., Crone, J.S., Schmid, E.V., Thomschewski, A., Butz, K., Schutze, V., Höller, P., & Trinka, E. (2013). Real movement vs. motor imagery in healthy subjects. Int J Psychophysiol, 87, 35-41. DOI: 10.1016/j.ijpsycho.2012.10.015

Höller, Y., Thomschewski, A., Schmid, E.V., Höller, P., Crone, J.S., & Trinka, E. (2012). Individual brain-frequency responses to self-selected music. Int J Psychophysiol, 86, 206-213. DOI: 10.1016/j.ijpsycho.2012.09.005

Höller, Y., Schmid, E.V., Crone, J.S. & Trinka, T. (2012) The effects of music and holistic pulsing on brain activity–preliminary observations from a quantitative single-case EEG study. Epileptologia, 20(1), 11-15. ISSN: 2081-9676

Crone, J.S., Ladurner, G., Höller, Y., Golaszewski, S., Trinka, E., & Kronbichler, M. (2011). Deactivation of the default mode network as a marker of impaired consciousness: an fMRI study. PLoS One,6, e26373. DOI: 10.1371/journal.pone.0026373

Höller, Y., Bergmann, J., Kronbichler, M., Crone, J.S., Schmid, E.V., Golaszewski, S., & Ladurner, G. (2011). Preserved oscillatory response but lack of mismatch negativity in patients with disorders of consciousness. Clin Neurophysiol, 122(9), 1744-1754. DOI: 10.1016/j.clinph.2011.02.009

Höller, Y., Kronbichler, M., Bergmann, J., Crone, J.S., Schmid, E.V., Golaszewski, S., & Ladurner, G. (2011). Inter-individual variability of oscillatory responses to subject’s own name. A single-subject analysis. Int J Psychophysiol, 80(3), 227-235. DOI: 10.1016/j.ijpsycho.2011.03.012

Höller, Y., Kronbichler, M., Bergmann, J., Crone, J.S., Ladurner, G., & Golaszewski, S. (2011). EEG frequency analysis of responses to the own-name stimulus. Clin Neurophysiol, 122, 99-106. DOI: 10.1016/j.clinph.2010.05.029

Edited Books and Chapters

Crone, J.S. (accepted). Context and complexity of aesthetic experiences. A neuroscientific view. In M. Scov & Nadal, M. (Eds). The Routledge International Handbook of Neuroaesthetics. Routledge.

Crone, J.S. (2023). The potential of causal approaches in creativity using ultrasonic brain stimulation. In R. Alby, Pelowski, M., & Spee, B.T.M. (Eds). Art and Neurodegenerative Disease—Illuminating the Intersection of Illness and Creativity. Current Clinical Neurology Book Series. Springer Nature. DOI: 10.1007/978-3-031-14724-1_10

Crone, J.S. & Monti, M.M. (2018). Consciousness. In M. H. Bornstein (Ed.), SAGE Encyclopedia of Lifespan Human Development. First Edition. Thousand Oaks: SAGE Publications. ISBN: 9781506307657

Crone, J.S. & Monti, M.M. (2018). Functional connectivity in disorders of consciousness. In C. Schnakers & Laureys, S. (Eds). Coma and disorders of consciousness. London: Springer. ISBN 978-3-319-55963-6

Crone, J.S. & Kronbichler, M. (2012). Neuroimaging in disorders of consciousness: Promises and problems. In R. Jox, Kuehlmeyer, K., Marckmann, G., Racine, E. (Eds.), Vegetative state – A paradigmatic problem of modern society: Medical, ethical, legal and social perspectives on chronic disorders of consciousness. Berlin: LIT-Verlag. ISBN 978-3-643-90097-5

Contact

j.crone @ neurocognition.org

Vienna Cognitive Science Hub | University of Vienna

Liebiggasse 5 | 1010 Vienna | Austria